The main objective of the DM4Manufacturing project is the integrated development of advanced robotics with decision making methodologies to maximize the productivity of the factories of the future. Robots will be able to collaborate with humans in a shared workspace in the shop-floor, creating a co-working partnership, and will receive manufacturing orders in a completely flexible manufacturing scenario. The decision-making tools will have to evolve to deal with production technologies with high flexibility, capable of performing different tasks with minimum reprogramming, capable of sensing the environment and working in environments designed for human-use. Following new paradigm, a human-centered automation methodologies, the DM4Manufacturing project will search the optimal automation level for each manufacturing scenario, to produce efficiently but also to promote better working environments. The expected impact of the DM4Manufacturing project is present in social, economic and scientific dimensions. Two industrial cases, automotive and aerospace, will be implemented and validated in laboratory non-controlled environments. The DM4Manufacturing vision and the consortium competences in technology transfer will allow to reduce the technological innovation gap that halts the transition from R&D to economic and social impact.